I have 50 or more Kindle books covering a wide-variety of genres and topics and I have a serious case of glaucoma which can make reading at certain points of the day very challenging.
A few minutes ago, I tried it and it works. The only thing I haven't figured out is how to direct the Echo to rewind to the beginning or to a specific chapter.
This is great for grandkids too. Now they can have a book read to them. Amazon's Kindle books for kids are plentiful.
Before the day is over today, I will experiment with this more.